Bone-titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography.
Identifieur interne : 000F11 ( PubMed/Checkpoint ); précédent : 000F10; suivant : 000F12Bone-titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography.
Auteurs : Anders Palmquist [Suède] ; Kathryn Grandfield ; Birgitta Norlindh ; Torsten Mattsson ; Rickard Br Nemark ; Peter ThomsenSource :
- Journal of the Royal Society, Interface [ 1742-5662 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Suède.
English descriptors
- KwdEn :
- MESH :
- chemical : Dental Implants, Titanium.
- geographic : Sweden.
- surgery : Jaw, Edentulous.
- ultrastructure : Bone and Bones.
- Aged, Electron Microscope Tomography, Humans, Male, Microscopy, Electron, Transmission, Osseointegration, Surface Properties.
Abstract
Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success. Analysis of interfacial zones at the micro- and nano-levels is essential to determine the extent of osseointegration. In this paper, a series of state-of-the-art microscopy techniques are used on laser-modified implants retrieved from humans. Partially laser-modified implants were retrieved after two and a half months' healing and processed for light and electron microscopy. Light microscopy showed osseointegration, with bone tissue growing both towards and away from the implant surface. Transmission electron microscopy revealed an intimate contact between mineralized bone and the laser-modified surface, including bone growth into the nano-structured oxide. This novel observation was verified by three-dimensional Z-contrast electron tomography, enabling visualization of an apatite layer, with different crystal direction compared with the apatite in the bone tissue, encompassing the nano-structured oxide. In conclusion, the present study demonstrates the nano-scale osseointegration and bonding between apatite and surface-textured titanium oxide. These observations provide novel data in human specimens on the ultrastructure of the titanium-bone interface.
DOI: 10.1098/rsif.2011.0420
PubMed: 21849383
Affiliations:
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first="Birgitta" last="Norlindh">Birgitta Norlindh</name></author><author><name sortKey="Mattsson, Torsten" sort="Mattsson, Torsten" uniqKey="Mattsson T" first="Torsten" last="Mattsson">Torsten Mattsson</name></author><author><name sortKey="Br Nemark, Rickard" sort="Br Nemark, Rickard" uniqKey="Br Nemark R" first="Rickard" last="Br Nemark">Rickard Br Nemark</name></author><author><name sortKey="Thomsen, Peter" sort="Thomsen, Peter" uniqKey="Thomsen P" first="Peter" last="Thomsen">Peter Thomsen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21849383</idno><idno type="pmid">21849383</idno><idno type="doi">10.1098/rsif.2011.0420</idno><idno type="wicri:Area/PubMed/Corpus">001274</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001274</idno><idno type="wicri:Area/PubMed/Curation">001274</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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uniqKey="Grandfield K" first="Kathryn" last="Grandfield">Kathryn Grandfield</name></author><author><name sortKey="Norlindh, Birgitta" sort="Norlindh, Birgitta" uniqKey="Norlindh B" first="Birgitta" last="Norlindh">Birgitta Norlindh</name></author><author><name sortKey="Mattsson, Torsten" sort="Mattsson, Torsten" uniqKey="Mattsson T" first="Torsten" last="Mattsson">Torsten Mattsson</name></author><author><name sortKey="Br Nemark, Rickard" sort="Br Nemark, Rickard" uniqKey="Br Nemark R" first="Rickard" last="Br Nemark">Rickard Br Nemark</name></author><author><name sortKey="Thomsen, Peter" sort="Thomsen, Peter" uniqKey="Thomsen P" first="Peter" last="Thomsen">Peter Thomsen</name></author></analytic><series><title level="j">Journal of the Royal Society, Interface</title><idno type="eISSN">1742-5662</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Bone and Bones (ultrastructure)</term><term>Dental Implants</term><term>Electron Microscope Tomography</term><term>Humans</term><term>Jaw, Edentulous (surgery)</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Osseointegration</term><term>Surface Properties</term><term>Sweden</term><term>Titanium</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Implants dentaires</term><term>Microscopie électronique à transmission</term><term>Mâchoire édentée ()</term><term>Mâle</term><term>Os et tissu osseux (ultrastructure)</term><term>Ostéo-intégration</term><term>Propriétés de surface</term><term>Sujet âgé</term><term>Suède</term><term>Titane</term><term>Tomographie en microscopie électronique</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term><term>Titanium</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Sweden</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electron Microscope Tomography</term><term>Humans</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Osseointegration</term><term>Surface Properties</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Implants dentaires</term><term>Microscopie électronique à transmission</term><term>Mâchoire édentée</term><term>Mâle</term><term>Os et tissu osseux</term><term>Ostéo-intégration</term><term>Propriétés de surface</term><term>Sujet âgé</term><term>Suède</term><term>Titane</term><term>Tomographie en microscopie électronique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suède</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success. Analysis of interfacial zones at the micro- and nano-levels is essential to determine the extent of osseointegration. In this paper, a series of state-of-the-art microscopy techniques are used on laser-modified implants retrieved from humans. Partially laser-modified implants were retrieved after two and a half months' healing and processed for light and electron microscopy. Light microscopy showed osseointegration, with bone tissue growing both towards and away from the implant surface. Transmission electron microscopy revealed an intimate contact between mineralized bone and the laser-modified surface, including bone growth into the nano-structured oxide. This novel observation was verified by three-dimensional Z-contrast electron tomography, enabling visualization of an apatite layer, with different crystal direction compared with the apatite in the bone tissue, encompassing the nano-structured oxide. In conclusion, the present study demonstrates the nano-scale osseointegration and bonding between apatite and surface-textured titanium oxide. These observations provide novel data in human specimens on the ultrastructure of the titanium-bone interface.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21849383</PMID><DateCompleted><Year>2012</Year><Month>09</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1742-5662</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>67</Issue><PubDate><Year>2012</Year><Month>Feb</Month><Day>07</Day></PubDate></JournalIssue><Title>Journal of the Royal Society, Interface</Title><ISOAbbreviation>J R Soc Interface</ISOAbbreviation></Journal><ArticleTitle>Bone-titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography.</ArticleTitle><Pagination><MedlinePgn>396-400</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1098/rsif.2011.0420</ELocationID><Abstract><AbstractText>Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success. Analysis of interfacial zones at the micro- and nano-levels is essential to determine the extent of osseointegration. In this paper, a series of state-of-the-art microscopy techniques are used on laser-modified implants retrieved from humans. Partially laser-modified implants were retrieved after two and a half months' healing and processed for light and electron microscopy. Light microscopy showed osseointegration, with bone tissue growing both towards and away from the implant surface. Transmission electron microscopy revealed an intimate contact between mineralized bone and the laser-modified surface, including bone growth into the nano-structured oxide. This novel observation was verified by three-dimensional Z-contrast electron tomography, enabling visualization of an apatite layer, with different crystal direction compared with the apatite in the bone tissue, encompassing the nano-structured oxide. In conclusion, the present study demonstrates the nano-scale osseointegration and bonding between apatite and surface-textured titanium oxide. These observations provide novel data in human specimens on the ultrastructure of the titanium-bone interface.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Palmquist</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. anders.palmquist@biomaterials.gu.se</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grandfield</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Norlindh</LastName><ForeName>Birgitta</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Mattsson</LastName><ForeName>Torsten</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Brånemark</LastName><ForeName>Rickard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Thomsen</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J R Soc Interface</MedlineTA><NlmUniqueID>101217269</NlmUniqueID><ISSNLinking>1742-5662</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>15FIX9V2JP</RegistryNumber><NameOfSubstance UI="C009495">titanium dioxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Biomaterials. 2004 May;25(10):1959-67</RefSource><PMID Version="1">14738860</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Mater Res B Appl Biomater. 2011 May;97(2):289-98</RefSource><PMID Version="1">21394900</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Oral Implants Res. 1991 Jul-Sep;2(3):103-11</RefSource><PMID Version="1">1843463</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biomaterials. 1996 Oct;17(19):1913-20</RefSource><PMID Version="1">8889073</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Oral Maxillofac Implants. 1997 Jul-Aug;12(4):486-94</RefSource><PMID Version="1">9274077</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Mater Res. 1998 Mar 15;39(4):611-20</RefSource><PMID Version="1">9492223</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Prosthodont. 2004 Sep-Oct;17(5):536-43</RefSource><PMID Version="1">15543910</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cochrane Database Syst Rev. 2007;(4):CD003815</RefSource><PMID Version="1">17943800</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Orthop. 2008 Feb;79(1):78-85</RefSource><PMID Version="1">18283577</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Mater Res A. 2008 Dec 15;87(4):1003-9</RefSource><PMID Version="1">18257067</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Mater Res A. 2010 Mar 15;92(4):1476-86</RefSource><PMID Version="1">19425049</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Mater Res A. 2010 Mar 15;92(4):1552-66</RefSource><PMID Version="1">19431206</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J R Soc Interface. 2010 Oct 6;7(51):1497-501</RefSource><PMID Version="1">20534599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biomaterials. 2011 Jan;32(2):374-86</RefSource><PMID Version="1">20933278</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nanomedicine. 2011 Apr;7(2):220-7</RefSource><PMID Version="1">21059406</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Oral Pathol. 1982 Aug;11(4):318-26</RefSource><PMID Version="1">6809919</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001842" MajorTopicYN="N">Bone and Bones</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055032" MajorTopicYN="N">Electron Microscope Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016348" MajorTopicYN="Y">Osseointegration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013548" MajorTopicYN="N" Type="Geographic">Sweden</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="Y">Titanium</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3243398</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21849383</ArticleId><ArticleId IdType="pii">rsif.2011.0420</ArticleId><ArticleId IdType="doi">10.1098/rsif.2011.0420</ArticleId><ArticleId IdType="pmc">PMC3243398</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Br Nemark, Rickard" sort="Br Nemark, Rickard" uniqKey="Br Nemark R" first="Rickard" last="Br Nemark">Rickard Br Nemark</name><name sortKey="Grandfield, Kathryn" sort="Grandfield, Kathryn" uniqKey="Grandfield K" first="Kathryn" last="Grandfield">Kathryn Grandfield</name><name sortKey="Mattsson, Torsten" sort="Mattsson, Torsten" uniqKey="Mattsson T" first="Torsten" last="Mattsson">Torsten Mattsson</name><name sortKey="Norlindh, Birgitta" sort="Norlindh, Birgitta" uniqKey="Norlindh B" first="Birgitta" last="Norlindh">Birgitta Norlindh</name><name sortKey="Thomsen, Peter" sort="Thomsen, Peter" uniqKey="Thomsen P" first="Peter" last="Thomsen">Peter Thomsen</name></noCountry><country name="Suède"><noRegion><name sortKey="Palmquist, Anders" sort="Palmquist, Anders" uniqKey="Palmquist A" first="Anders" last="Palmquist">Anders 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